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The effectiveness of orlistat in promoting weight loss is definite, though modest. Half of the data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2-3 kilograms (4.4-6.6 lb) more than those who do not take the drug over the course of a year. Orlistat also modestly reduces blood pressure and seems to prevent the onset of type 2 diabetes either due to its own weight loss or other effects; In a large randomized controlled trial, orlistat was found to reduce the incidence of diabetes by nearly 40% in obese people.
Usual Adult Dose for Obesity: 120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.
Usual Pediatric Dose for Obesity (12 years or older): 120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.